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  • Encephalitis: recent advances and challenges ahead
  • Posted in Clinical Review Article

  • 06th Dec 2012

  • Coma accompanying fever, which now would be termed encephalitis, was described by Sydenham as early as the 17th century, although associations between fever and brain dysfunction were recognised even earlier. Since then, much progress has been made in understanding the causes, biological mechanisms, epidemiology and treatment of encephalitis; however, numerous gaps still exist in our knowledge…

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  • Primary Progressive Multiple Sclerosis
  • Posted in Clinical Review Article

  • 18th Sep 2012

  • MS is the commonest non-traumatic disabling disease to affect young adults in the UK. Although current dogma states that it is an organ-specific autoimmune disease of the central nervous system the antigenic targets of the autoimmune attack have yet to be identified. Despite the cause of MS remaining undefined there is an increasing understanding of the causal pathways that underlie the disease. MS is considered by most to be a complex disease due to an interaction between genetic and environmental factors.