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  • Hippocampal Plasticity – An Update
  • Posted in Clinical Review Article

  • 19th Jun 2013

  • It is forty years since the first full report of long-term potentiation (LTP), a presumed cellular substrate for learning and memory. This review will provide an update on some recent advances in our understanding of the mechanisms underlying hippocampal LTP and address their potential clinical relevance. Introduction The hippocampus plays a fundamental role in learning […]

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  • New Developments in Susac’s Syndrome
  • Posted in Clinical Review Article

  • 13th Mar 2013

  • The diagnosis of Susac’s syndrome has been facilitated greatly by appreciation of distinctive magnetic resonance imaging (MRI) findings. As a result there is now increased recognition of what was once thought to be a very rare disease. The aim of this review is to provide an update on the latest developments in Susac’s syndrome and […]

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  • Inherited Ion Channel Disorders of the Brain
  • Posted in Clinical Review Article

  • 31st Jan 2013

  • The last two decades have witnessed a rapid increase in the number of inherited disorders caused by ion channel mutations. One of the major challenges is to delineate the full clinical spectrum of these ‘channelopathies’. Among this expanding group, neurological ion channel disorders are among the best characterised, reflecting the fundamental importance of electrical excitability […]

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  • Acupuncture for Headache
  • Posted in Clinical Review Article

  • 31st Jan 2013

  • Acupuncture has a long history as part of Chinese medicine. In Western countries it is now one of the major complementary therapies, with lifetime use in adult populations as high as 34%.1 Headache is one of the more common presenting conditions in acupuncture general practice2 and use of the therapy by headache sufferers in tertiary […]

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  • Encephalitis: recent advances and challenges ahead
  • Posted in Clinical Review Article

  • 06th Dec 2012

  • Coma accompanying fever, which now would be termed encephalitis, was described by Sydenham as early as the 17th century, although associations between fever and brain dysfunction were recognised even earlier. Since then, much progress has been made in understanding the causes, biological mechanisms, epidemiology and treatment of encephalitis; however, numerous gaps still exist in our knowledge…

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  • Primary Progressive Multiple Sclerosis
  • Posted in Clinical Review Article

  • 18th Sep 2012

  • MS is the commonest non-traumatic disabling disease to affect young adults in the UK. Although current dogma states that it is an organ-specific autoimmune disease of the central nervous system the antigenic targets of the autoimmune attack have yet to be identified. Despite the cause of MS remaining undefined there is an increasing understanding of the causal pathways that underlie the disease. MS is considered by most to be a complex disease due to an interaction between genetic and environmental factors.

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