The immunomodulatory role of Therapeutic Plasma exchange in Neuromuscular and PNS diseases: a practical approach & new knowledge
Posted in Courses & Conferences on 9th Apr 2018
Workshop details: International workshop by Excemed, Saturday, May 19 2018, Royal College of Physicians, London.
Published online: 9/4/18
Autoimmune-mediated diseases affecting the peripheral nervous system (PNS) are a group of pathologies usually associated with an aggressive course and high clinical disability. A prompt diagnosis and correct course of treatment are fundamental in order to limit functional impairment and prevent clinical relapses.
The clinical picture of autoimmune mediated polyneuropathies ranges from the acute inﬂammatory demyelinating polyneuropathy (AIDP), to the chronic inﬂammatory demyelinating polyneuropathy (CIDP), with all its sub forms, each with speciﬁc clinical presentations. Along with the peripheral nervous system, the neuromuscular plaque can also be affected by antibodies and pathogenic activity, causing myasthenia gravis.
While in some types of autoimmune-mediated PNS diseases the related causative antibodies are well known, among others the pathogenic role of the immune system is only hypothesised. The best treatment approach is to remove auto antibodies targeting the PNS. The gold standard treatment is ﬁnalised to quickly remove autoantibodies targeting the PNS.
This workshop will review the main clinical and pathogenic features of immune-mediated PNS disorders and discuss the rationale and utility of therapeutic plasma exchange.
More information here.