Migraine and vestibular dysfunction

Posted in Headache on 22nd Aug 2014

Summary

  • Vestibular symptoms  in migraine are disabling and may be the dominant feature leading to inaccurate diagnosis
  • Recurrent episodic vertigo is common in migraineurs and most frequently due to the  migraine process itself
  • Co-morbid peripheral vestibular disorders occur at higher prevalence in migraineurs
  • Vestibular dysfunction can be a trigger in migraine and needs due recognition
  • Vestibular migraine is the chameleon to spot as the drive is migrainous but the course of vertigo is highly variable in duration, attack frequency and association with cephalagia- with the latter not infrequently attenuated.  For pointers to identifying the vestibular dysfunction see Table 1.

 

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The association of vestibular aura/dysfunction with migraine is often under-recognised leading to delayed treatment, adding further to the burden of disability migraineurs suffer. Migraine is one of the commonest neurological complaints with a lifetime prevalence of 16%, with headache representing one fifth of neurology outpatient referrals.1 It is recognised by WHO to be ranked amongst the top 10 most disabling conditions with psychiatric morbidity at the top of the league table. Vertigo is also extremely common with a life-time prevalence in adulthood of 7%, having a significant psycho-social impact. Migraineurs are more likely to suffer from vertigo with 3.2% affected and this is in excess of the anticipated co-morbid prevalence of 1.1%.2 This cohort of migraineurs with vestibular dysfunction, have significant associated psychiatric morbidity with the highest indices of anxiety reported in vertiginous cohorts with vestibular migraine.3

Whilst cephalgia is typically the most prominent complaint, vestibular disturbance can predominate as part of an aura presentation – brainstem aura – or through parallel dysfunction in vestibular pathways – vestibular migraine – or as co-morbid vestibular disorders such as BPPV and Meniere’s. Discriminating between the centrally driven migrainous process and peripheral lesions is important to tailor treatments and direct management.

Common vestibular disorders in migraine

Recurrent vertigo is most common in migraineurs and although this is frequently migrainous in origin, the high prevalence of vestibular disorders raises the question of overlapping pathophysiology.

Benign Paroxysmal Positional Vertigo (BPPV):

Transient vertigo due to BPPV is common, with attacks typically lasting seconds and recurring over several weeks but usually self-limiting. It is triggered by specific changes in the position of the head and is caused by the movement of displaced otolith crystals within the semi-circular canals. In tertiary neuro-otology clinics BPPV is one of the most common underlying diagnoses; accounting for a fifth of cases in the 5000 cases reviewed at the Munich centre.4 In those with idiopathic BPPV they are however twice as likely to have co-morbid migraine.5 BPPV in this patient group needs to be independently treated with canalith repositioning manoeuvres, particularly given that the vestibular presentation may serve as a trigger for migraine.

Meniere’s Disease:

The differentiation between Meniere’s and migraine in a single acute vertiginous attack with emesis and headache is often difficult. However repeated attacks allow for discrimination of Meniere’s: with audiometrically evident hearing loss (typically unilateral although can become bilateral over time, rarely alternating between ears) and horizontal nystagmus which may initially only be manifest during the attack. In addition to profound vertigo lasting typically in excess of 20 minutes, report of tinnitus or aural fullness together with progressive hearing loss is diagnostic.4 The condition is driven by endolymphatic hydrops with paraclinical supporting evidence of significant audiological loss and peripheral vestibular dysfunction on oculographic calorics. Once again migraine is twice as common in this group6 and with audiological loss fluctuating it may not be captured on pre-arranged testing in the early stages and testing at the time of the attack should be pursued if there is any doubt. Treatment for Meniere’s includes a low salt diet, diuretics and high dose betahistine.

The relationship between migraine and Meniere’s remains unclear however a causal relationship has been questioned following the observation that those with migraine develop Meniere’s earlier and more frequently have bilateral hearing loss.7

Migraine in association with vestibular symptoms

Two migraine phenotypes are recognised in the international classification of headache disorders (ICHD version 3 beta:8) with prominent vestibular symptoms: Migraine with brainstem aura and Vestibular migraine.

Migraine with brainstem aura
ja-headache-box-1Having previously been called basilar artery migraine in reference to the presumed unifying arterial pathophysiology, our current understanding of migraine has taken us beyond a primary vascular aetiology (as outlined by Holland and Afridi, ACNR 2014;V13(7):19-21) and this is recognised by the ICHD in renaming this as migraine with brainstem aura. Whilst vestibular dysfunction may occur in this phenotype, in association with other brainstem aura phenomena, its presence is in keeping with aura and as such the duration of the vertiginous attack is consistent with that of Leao’s cortical spreading depression lasting one hour. Two or more brainstem mediated phenomena evolving or occurring in succession over more than five minutes include: vertigo, tinnitus, hypoacusis, diplopia, bilateral visual symptoms, simultaneous bilateral sensory paraesthesia, ataxia, loss of consciousness. This is in conjunction with migrainous unilateral, throbbing, moderate to severe headache, starting during or within one hour of the aura and lasting more than four hours with hypersensitivity to external sensory stimuli (photophobia, phonophobia, osmophobia) and typical aggravation on routine physical activity. Please refer to Box 1 for summary of ICHD3beta diagnostic criteria for migraine with brainstem aura.

Migraine with brainstem aura is rare in both migraine and neuro-otology, occurring in 10% of those with migraine with aura.9

Vestibular migraine

Vestibular migraine with vestibular symptoms in isolation of other brainstem aura is much more common accounting for up to 10% of patients seen in tertiary neuro-otology dizzy clinics.4 Please refer to box 2 which details the ICHD3beta diagnostic criteria for vestibular migraine. ja-headache-box-2Importantly the duration of vertigo can be very variable and in up to 70% is not in keeping with aura duration: lasting seconds, hours or days. In addition the association with cephalgia is variable with only 48% reporting consistent cephalgia although migrainous associated symptoms of phonophobia and photophobia are more prevalent.
Vertigo can occur at any time point during the migrainous episode, with the attack frequency being highly variable with days to years between events. The average age of onset of vertiginous attacks post-dates the onset of migraine by years and migraine may have become quiescent, with the headache during the vertiginous attacks often attenuated – emphasising the utility of a directed interrogation of former migraine in those presenting with recurrent episodic vertigo.10 Trigger factors precipitating attacks may also prove useful as the episodes are often triggered by well-established migraine triggers as detailed in the summary table. Ultimately further diagnostic clarity can be derived from the good response to treatment with anti-migraine preventatives. In clinical practise the full array of migraine preventatives are used including beta blockers, tricyclic antidepressants, anti-epileptics (topiramate, sodium valproate etc.), serotonergic (pizotifen) drugs and calcium channel blockers (flunarazine) – the latter with anecdotal significant utility. Unfortunately clinical drug trials in vestibular migraine remain either underpowered or compounded by lack of rigour in diagnostic inclusion.

Distinct from Meniere’s disease, significant progressive hearing loss or vestibular deficit are not a persistent feature in vestibular migraine. The diagnosis of vestibular migraine should be based on the history as there are no diagnostic findings on examination or audio-vestibular assessment. Significant nystagmus in the migraineur should be treated with caution and a peripheral cause considered in those with otherwise normal examination and no clinical pointers to central disorders. Unilateral hypo-excitability on calorics without associated pathological nystagmus however should not raise concern as this simply indicates prior centrally compensated peripheral vestibular deficit. In both BBPV and vestibular migraine head motion precipitated vertigo occurs: in BBPV this is fatigable and self-limiting, with an abnormal examination whilst symptomatic; whilst the vertigo of vestibular migraine is recurrent, non-fatigable and with a typically normal examination when symptomatic.

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Vestibular trigger to migraine

Discerning the underlying cause of vertigo in migraine is paramount as it will enable both tailored treatment and in the case of co-morbid peripheral vestibular disorders will also serve to reduce a potential migraine trigger. In a prospective study of the incidence of migraine in the 24 hour period following vestibular testing (including calorics) almost a half of migraineurs studied recorded migraine and this frequently occurred during the induced vertigo.11 This underlies the need to carefully interrogate presentations where vertigo just precedes the onset of migraine and not assume that this is vestibular migraine.

Motion sickness

Motion sickness can be defined as prolonged symptoms of dysequilibrium in conjunction with nausea provoked by movement or the illusory perception of movement. In migraineurs, contrary to other peripheral disorders, there is a high prevalence of motion sickness with approximately two thirds affected either with an antecedent or concurrent history.12,13 Current theories in migraine associated phenomena focus on sensory dysmodulation. It is proposed that motion sickness highlights failure of normal integration of vestibular, visual and proprioceptive cues with disruption of normal inhibitory gating mechanisms in the brainstem responsible for hypersensitivity of the emetic centre, sharing a similar underlying pathophysiology to migraine (for comprehensive review: 14). In movement induced motion sickness the principal mediator is the vestibular apparatus with experiments showing complete attenuation of this phenomenon in those without a functional vestibular apparatus. However visual induced motion sickness is not directly mediated by the vestibular apparatus but rather reflects dysmodulation of converging sensory inputs, and is more frequently seen in migraineurs compared to controls.15

References

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  2. Neuhauser HK, Radtke A, von Brevern M, Lezius F, Feldmann M, Lempert T. Burden of dizziness and vertigo in the community. Archives of internal medicine 2008;168:2118-2124.
  3. Eckhardt-Henn A, Best C, Bense S, et al. Psychiatric comorbidity in different organic vertigo syndromes. Journal of neurology 2008;255:420-428.
  4. Brandt T, Strupp M. Migraine and vertigo: Classification, clinical features, and special treatment considerations. Headache Currents 2006;3:12-19.
  5. Lempert T, Leopold M, von Brevern M, Neuhauser H. Migraine and benign positional vertigo. The Annals of otology, rhinology, and laryngology 2000;109:1176.
  6. Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in Meniere’s disease. American Academy of Otolaryngology-Head and Neck Foundation, Inc. Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 1995;113:181-185.
  7. Cha YH, Brodsky J, Ishiyama G, Sabatti C, Baloh RW. The relevance of migraine in patients with Meniere’s disease. Acta oto-laryngologica 2007;127:1241-1245.
  8. Headache Classification Committee of the International Headache S. The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia : an international journal of headache 2013;33:629-808.
  9. Kirchmann M, Thomsen LL, Olesen J. Basilar-type migraine: clinical, epidemiologic, and genetic features. Neurology 2006;66:880-886.
  10. Neuhauser H, Leopold M, von Brevern M, Arnold G, Lempert T. The interrelations of migraine, vertigo, and migrainous vertigo. Neurology 2001;56:436-441.
  11. Murdin L, Davies RA, Bronstein AM. Vertigo as a migraine trigger. Neurology 2009;73:638-642.
  12. Baloh RW. Neurotology of migraine. Headache 1997;37:615-621.
  13. Marcus DA, Furman JM, Balaban CD. Motion sickness in migraine sufferers. Expert opinion on pharmacotherapy 2005;6:2691-2697.
  14. Cuomo-Granston A, Drummond PD. Migraine and motion sickness: what is the link? Progress in neurobiology 2010;91:300-312.
  15. Drummond PD, Granston A. Facial pain increases nausea and headache during motion sickness in migraine sufferers. Brain:a journal of neurology 2004;127:526-534.

To cite:
Anderson JM. ACNR 2014;14(3):12-14.

Copyright:
Boxes 1 and 2 are taken/adapted from text in the International Classification of Headache Disorders- version 3 beta and are reproduced with permission.

ACNR 2014;V14(3):12-14. Online 22/8/14

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